Necroptosis

坏死性凋亡

英文解释

Necroptosis is a regulated necrotic cell death modality in a caspase-independent fashion and is mainly mediated by Receptor-Interacting Protein 1 (RIP1), RIP3, and Mixed Lineage Kinase Domain-Like (MLKL). Necroptosis serves as an alternative mode of Programmed cell death (PCD) overcoming apoptosis resistance.

中文解释

坏死性凋亡是一种不依赖半胱天冬酶的受调节的坏死细胞死亡方式，主要由受体相互作用蛋白 1 Receptor-Interacting Protein 1 (RIP1)、RIP3 和混合谱系激酶域样 (MLK??L) 介导。坏死性凋亡可作为程序性细胞死亡 Programmed cell death (PCD) 克服细胞凋亡抗性的替代模式。

参考文献

[1]. Yitao Gong, et al. The role of necroptosis in cancer biology and therapy. Mol Cancer. 2019 May 23;18(1):100.