Negative allosteric modulator (NAM)

负变构调节剂

英文解释

Negative allosteric modulators (NAMs) represent a novel and indirect approach to attenuate signaling by decreasing affinity and/or efficacy of ligands.

中文解释

负变构调节剂 (NAM) 代表了一种通过降低配体的亲和力和/或功效来减弱信号传导的新型间接方法。

参考文献

[1]. Vishakh Iyer, et al. Negative allosteric modulation of CB1 cannabinoid receptor signaling suppresses opioid-mediated reward. Pharmacol Res. 2022 Nov;185:106474.