nuclear factor-κB (NF-κB)

核因子-κB

英文解释

Nuclear factor-κB (NF-κB) is a transcription complex crucial for host defense mediated by innate and adaptive immunity, where canonical NF-κB signaling, mediated by nuclear translocation of RelA, c-Rel, and p50, is important for immune cell activation, differentiation, and survival.

中文解释

核因子-κB (NF-κB) 是一种转录复合体，对先天免疫和适应性免疫介导的宿主防御至关重要，其中典型的 NF-κB 信号通路，由 RelA、c-Rel 和 p50 的核易位介导，对免疫细胞的激活、分化和存活非常重要。

参考文献

[1]. Miraghazadeh B, Cook MC. Nuclear Factor-kappaB in Autoimmunity: Man and Mouse. Front Immunol. 2018 Apr 9;9:613.