Oligonucleotide

寡核苷酸

英文解释

Oligonucleotides are short DNA or RNA linear molecules. Oligonucleotides can be used to modulate gene expression via a range of processes including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation, non-coding RNA inhibition, gene activation and programmed gene editing.

中文解释

寡核苷酸是短的 DNA 或 RNA 线性分子。寡核苷酸可以通过一系列过程来调节基因表达，包括 RNAi、RNase h 介导的切割靶降解、剪接调制、非编码 RNA 抑制、基因激活和程控基因编辑。

参考文献

[1]. Roberts TC, et al. Advances in oligonucleotide drug delivery. Nat Rev Drug Discov. 2020 Oct;19(10):673-694.