Oxidase (MAO)

单胺氧化酶

英文解释

Monoamine oxidase (MAO) is a flavin adenine dinucleotide (FAD)-dependent enzyme found in the outer mitochondrial membrane of neuronal, glial, and other mammalian cells. MAO is a useful target in the treatment of Neurodegenerative diseases (NDDs) and depressive disorders. Both isoforms, MAO-A and MAO-B, are known to play critical roles in disease progression.

中文解释

单胺氧化酶 (MAO) 是一种黄素腺嘌呤二核苷酸 (FAD) 依赖性酶，存在于神经元、神经胶质和其他哺乳动物细胞的线粒体外膜中。MAO 是治疗神经退行性疾病 神经退行性疾病 和抑郁症的有用靶标。 已知两种亚型 MAO-A 和 MAO-B 在疾病进展中起关键作用。

参考文献

[1]. Giovanna L Delogu, et al. Monoamine oxidase (MAO) inhibitory activity: 3-phenylcoumarins versus 4-hydroxy-3-phenylcoumarins. ChemMedChem. 2014 Aug;9(8):1672-6.