Pancreatic ductal adenocarcinomas (PDAC)

胰腺导管腺癌

英文解释

Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by a poor prognosis and high mortality rate.The typical histopathology of PDAC comprises clusters of moderately-to-poorly differentiated cancer cells embedded within an exuberant desmoplastic stroma, consisting of Extracellular matrix (ECM), Cancer-associated fibroblasts (CAFs) and immune cells.

中文解释

胰腺导管腺癌 (PDAC) 是一种以预后不良和高死亡率为特征的恶性肿瘤。PDAC 的典型组织病理学包括嵌入在旺盛的促纤维增生基质内的中度至低分化癌细胞簇，由细胞外基质 Extracellular matrix (ECM)、癌症相关成纤维细胞 Cancer-associated fibroblasts (CAFs) 和免疫细胞。

参考文献

[1]. Yunzhen Qian, et al. Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma. J Hematol Oncol. 2020 Oct 2;13(1):130.
[2]. Jincheng Han, et al. Single-cell RNA sequencing in pancreatic cancer. Nat Rev Gastroenterol Hepatol. 2021 Jul;18(7):451-452.