Patient-derived xenograft models (PDX)

患者来源的异种移植模型

英文解释

Patient-derived xenograft models (PDX) is a xenograft model, which fresh tumor tissue or tumor cells from a patient are transplanted in situ or ectopic into immunodeficient mice and grown in the environment provided by the mice.PDX is widely used as preclinical cancer models, which represents the genomic features of primary tumors.

中文解释

患者来源的异种移植模型（PDX）是一种异种移植模型，将来自患者的新鲜肿瘤组织或肿瘤细胞原位或异位移植到免疫缺陷小鼠中，并在小鼠提供的环境中生长。PDX 广泛用作临床前癌症模型 ，它代表了原发性肿瘤的基因组特征。

参考文献

[1]. Uri Ben-David, et al. Patient-derived xenografts undergo mouse-specific tumor evolution. Nat Genet. 2017 Nov;49(11):1567-1575.
[2]. Jiahao Shi, et al. The fidelity of cancer cells in PDX models: Characteristics, mechanism and clinical significance. Int J Cancer. 2020 Apr 15;146(8):2078-2088.