Phosphodiesterase-4 (PDE4)

磷酸二酯酶 4

英文解释

Phosphodiesterase-4 (PDE4) is a enzyme belongs to Phosphodiesterase (PDE), is responsible for the degradation of cAMP and cGMP. Phosphodiesterase-4 (PDE4) involves in the regulation of proinflammatory cytokines via the degradation of cyclic adenosine monophosphate.

中文解释

磷酸二酯酶 4 (PDE4)，是一种属于 Phosphodiesterase (PDE) 的酯酶，负责降解 cAMP and cGMP。磷酸二酯酶 4 降解环磷酸腺苷参与调节促炎细胞因子。

参考文献

[1]. Zebda R, et al. Phosphodiesterase 4 inhibitors. J Am Acad Dermatol. 2018 Mar;78(3 Suppl 1):S43-S52.
[2]. Bhat A, et al. Phosphodiesterase-4 enzyme as a therapeutic target in neurological disorders. Pharmacol Res. 2020 Oct;160:105078.