Poly(ADP-ribose)polymerase-1 (PARP1)

英文解释

Poly(ADP-ribose)polymerase-1 (PARP1) is a DNA repair enzyme highly expressed in the nuclei of mammalian cells. PARP inhibitor has efficacy at sub-cytotoxic concentrations in radiosensitizing multiple human cancer cell lines to ionizing radiation.

中文解释

Poly(ADP-ribose)polymerase-1 (PARP1) 是一种在哺乳动物细胞核中高度表达的 DNA 修复酶 。PARP 抑制剂在亚细胞毒性浓度下具有使多种人类癌细胞系对电离辐射放射敏感的功效。

参考文献

[1]. Stephen A Jannetti, et al. Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy. Front Pharmacol. 2020 Mar 3;11:170.