Polybromo-1 (PBRM1)

英文解释

Polybromo-1 (PBRM1)is a member of the bromodomain family VIII, is a subunit of the PBRM1-BRG1/BRM-associated factors (PBAF) complex, uniquely contains six consecutive bromodomains, also is a member of the Adenosine triphosphate (ATP)-dependent SWItch/sucrose nonfermenting (SWI/SNF) chromatin remodeling complex family.

中文解释

Polybromo-1 是溴域家族 VIII 的成员，是 PBRM1- brg1/brm 相关因子 (PBAF) 复合体的一个亚基，唯一包含 6 个连续的溴域，也是 Adenosine triphosphate (ATP) 依赖性 SWItch/蔗糖非发酵(SWI/SNF) 染色质重塑复合体家族的成员。

参考文献

[1]. Shifali Shishodia, et al. Selective andCell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR FragmentScreening. J Med Chem. 2022 Oct 13.