Programmed cell death ligand 1 (PD-L1)

程序性细胞死亡配体 1

英文解释

Programmed cell death ligand 1 (PD-L1) is a ligand of Programmed death receptor 1 (PD-1). PD-L1 is expressed in several human tumor tissues, and is able to effectively inhibit the activation, proliferation and secretion of cytokines related to T cells, the immune response and to induce T-cell failure or even apoptosis upon binding to PD-1.

中文解释

程序性细胞死亡配体 1 (PD-L1) 是程序性死亡受体 1 Programmed death receptor 1 (PD-1) 的配体。PD-L1 在多种人体肿瘤组织中表达，并能有效抑制 T 细胞相关细胞因子的激活、增殖和分泌，抑制免疫反应，与 PD-1 结合后可诱导 T 细胞失效甚至凋亡。

参考文献

[1]. Yang X, Liu J. Targeting PD-L1 (Programmed death-ligand 1) and inhibiting the expression of IGF2BP2 (Insulin-like growth factor 2 mRNA-binding protein 2) affect the proliferation and apoptosis of hypopharyngeal carcinoma cells. Bioengineered. 2021 Dec;12(1):7755-7764.