Protein kinase A (PKA)

蛋白激酶 A

英文解释

Protein kinase A (PKA), the Cyclic adenosine monophosphate (cAMP)-dependent protein kinase, is ubiquitously expressed in mammalian cells, can be activated in response to a plethora of biological stimuli, and phosphorylates more than 250 known substrates. PKA serves as the primary effector of the second-messenger molecule 3',5'-cyclic adenosine monophosphate (cAMP), has mostly inhibitory effects on the adaptive immune response. PKA has a wide range effects in energy homeostasis, memory formation and immunity.

中文解释

蛋白激酶 A (PKA) 是一种 Cyclic adenosine monophosphate (cAMP) 依赖性蛋白激酶，在哺乳动物细胞中普遍表达，可响应过多的生物刺激而被激活，并使 250 多种已知底物磷酸化。PKA 作为第二信使分子 3',5'-环磷酸腺苷 (cAMP) 的主要效应物，主要对适应性免疫反应具有抑制作用。PKA 在能量稳态、记忆形成和免疫方面具有广泛的作用。

参考文献

[1]. Thomas S Postler, et al. A most versatile kinase: The catalytic subunit of PKA in T-cell biology. Int Rev Cell Mol Biol. 2021;361:301-318.