Pyruvate dehydrogenase kinase 1 (PDK1)

丙酮酸脱氢酶激酶 1

英文解释

Pyruvate dehydrogenase kinase 1 (PDK1) is a key regulatory enzyme in glucose metabolism, inactivates the TCA cycle enzyme, pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl-CoA.

中文解释

丙酮酸脱氢酶激酶 1 (PDK1) 是糖代谢的关键调节酶，使 TCA 循环酶丙酮酸脱氢酶 (PDH) 失活，使丙酮酸转化为乙酰辅酶 A。

参考文献

[1]. Kim JW, et al. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006 Mar;3(3):177-85.