Pyruvate dehydrogenase kinase 3 (PDK3)

丙酮酸脱氢酶激酶 3

英文解释

Pyruvate dehydrogenase kinase 3 (PDK3) is a multifunctional enzyme that plays a central role in the cancer metabolic switch by blocking pyruvate catabolism in the TCA cycle.

中文解释

丙酮酸脱氢酶激酶 3 (PDK3) 是一种多功能酶，通过阻断 TCA 循环中的丙酮酸分解代谢，在癌症代谢切换中发挥核心作用。

参考文献

[1]. Mohammad T, et al. Identification of high-affinity inhibitors of pyruvate dehydrogenase kinase-3: towards therapeutic management of cancer. J Biomol Struct Dyn. 2021 Feb;39(2):586-594.