Pyruvate dehydrogenase kinases (PDKs)

丙酮酸脱氢酶激酶

英文解释

Pyruvate dehydrogenase kinases (PDKs) are key enzymes in the pathway of glucose metabolism, could inactivate the Pyruvate dehydrogenase complex (PDC) by phosphorylating it and preserving the substrates pyruvate, lactate and alanine for gluconeogenesis.

中文解释

丙酮酸脱氢酶激酶 (PDKs) 是糖代谢途径中的关键酶，可通过磷酸化使 Pyruvate dehydrogenase complex (PDC) 失活，保存底物丙酮酸、乳酸和丙氨酸，促进糖异生。

参考文献

[1]. Zhang W, et al. Targeting Tumor Metabolism forCancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable AnticancerTarget? Int J Biol Sci. 2015 Nov 1;11(12):1390-400.