Raf family

Raf 家族

英文解释

Raf family are conserved, ubiquitous serine/protein kinases. The Raf protein kinases are key intermediates in cellular signal transduction, functioning as direct effectors of the RAS GTPases and as the initiating kinases in the Extracellular signal-regulated kinases (ERKs) cascade. Raf family includes A-Raf, B-Raf and C-Raf, possess a Ras-binding domain (RBD) in their N-terminal regulatory region and can function as effectors of active GTP-bound RAS family

中文解释

Raf 家族是保守的、普遍存在的丝氨酸/蛋白激酶。Raf 蛋白激酶是细胞信号转导中的关键中间体，作为 RAS GTP 酶的直接效应物和 Extracellular signal-regulated kinases (ERKs) 级联中的起始激酶发挥作用。Raf 家族包括 A-Raf、B-Raf 和 C-Raf，在其 N 末端调节区中具有 Ras 结合结构域 (RBD)，可作为活性 GTP 结合 RAS family 的效应子发挥作用。

参考文献

[1]. G Maurer, et al. Raf kinases in cancer-roles and therapeutic opportunities. Oncogene. 2011 Aug 11;30(32):3477-88.
[2]. David E Durrant, et al. Targeting the Raf kinases in human cancer: the Raf dimer dilemma. Br J Cancer. 2018 Jan;118(1):3-8.