RAS family

RAS 家族

英文解释

Ras family is the most frequently mutated gene family in cancers. RAS is a small switch signalling GTPase that toggles between its Guanosine 5′-triphosphate (GTP)-bound active state and the GDP-bound inactive state.

中文解释

Ras 家族是癌症中突变最频繁的基因家族。RAS 是一个小开关信号 GTPase，它在其 Guanosine 5′-triphosphate (GTP) 绑定的活动状态和 GDP 绑定的非活动状态之间切换。

参考文献

[1]. Amanda R Moore, et al. RAS-targeted therapies: is the undruggable drugged? Nat Rev Drug Discov. 2020 Aug;19(8):533-552.