Retinoic acid-inducible gene 1-like receptors (RLRs)

视黄酸诱导基因 1 样受体

英文解释

Retinoic acid-inducible gene 1-like receptors (RLRs) are expressed at low levels, but their expression is induced by type I interferon (IFN) or a viral infection. RLRs function as sensors for the detection of viral RNA (such as double-stranded RNA) in the cytoplasm , and initiatse antiviral responses by producing type I and type III IFNs.

中文解释

视黄酸诱导基因 1 样受体 (RLR) 通常以低水平表达，但它们的表达可由 I 型干扰素 (IFN) 或病毒感染诱导上调。RLR 作为传感器检测细胞质中的病毒 RNA (如双链 RNA)，并通过产生 I 型和 III 型 IFN 启动抗病毒反应。

参考文献

[1]. Onoguchi K, et al. Retinoic acid-inducible gene-I-like receptors. J Interferon Cytokine Res. 2011 Jan;31(1):27-31.