SET domain-containing lysine methyltransferase 7 (SETD7, also called SET7, SET9, KMT7)

含 SET 结构域的赖氨酸甲基转移酶 7

英文解释

SET domain-containing lysine methyltransferase 7 (SETD7) belongs to the protein lysine methyltransferase family and can catalyze the monomethylation of histone H3K4, which plays a vital role in the regulation of cell cycle, cell differentiation, DNA damage response and chromatin remodeling through K/R-S/T-K (K is lysine residue) sites and the recognition of substrates mediated by SET, i-SET, and n-SET domains and electrostatic action. SETD7 also can regulate the transcription of several genes including β-catenin, Cullin l and lin-28 homolog A (LIN28A), etc.

中文解释

含 SET 结构域的赖氨酸甲基转移酶 7 (SETD7) 属于蛋白质赖氨酸甲基转移酶家族，可催化组蛋白 H3K4 的单甲基化，通过 K/R-S/T-K (K 为赖氨酸残基)位点，以及 SET、i-SET、n-SET 结构域和静电作用介导的底物识别，在调节细胞周期、细胞分化、DNA 损伤反应和染色质重塑中发挥重要作用。SETD7 还能调控 β-catenin、Cullin l 和 lin-28 同源物 A (LIN28A) 等基因的转录。

参考文献

[1]. Yang S, et al. The role of SET domain containing lysine methyltransferase 7 in tumorigenesis and development. Cell Cycle. 2022 Sep 13:1-7.