Sirtuin1 (SIRT1)

Sirtuin1

英文解释

Sirtuin1 (SIRT1) is a class-III histone deacetylase (HDAC), an NAD+-dependent enzyme deeply involved in gene regulation, genome stability maintenance, apoptosis, autophagy, senescence, proliferation, aging, and tumorigenesis. It also has a key role in the epigenetic regulation of tissue homeostasis and many diseases by deacetylating both histone and non-histone targets.

中文解释

Sirtuin1 (SIRT1) 是一种 iii 类组蛋白去乙酰化酶 (HDAC)，是一种 NAD+ 依赖性酶，深度参与基因调控、基因组稳定维护、凋亡、自噬、衰老、增殖、衰老和肿瘤发生。通过脱乙酰组蛋白和非组蛋白靶点，它在组织稳态和许多疾病的表观遗传调控中也起着关键作用。

参考文献

[1]. Alves-Fernandes DK, et al. The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer. Int J Mol Sci. 2019 Jun 28;20(13):315