Soluble epoxide hydrolase (sEH)

可溶性环氧化物水解酶

英文解释

Soluble epoxide hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively maintain endogenous epoxyeicosatrienoic acids (EETs) levels and reduce dihydroxyeicosatrienoic acids (DHETs) levels, resulting in therapeutic potentials for cardiovascular, central nervous system, and metabolic diseases.

中文解释

可溶性环氧化物水解酶 (sEH) 是一种 α/β 水解酶折叠蛋白，广泛分布于肝、肾、脑等众多器官中。sEH 的抑制可以有效维持内源性环氧二烯三烯酸 (EETs) 水平，降低二羟二烯三烯酸 (DHETs) 水平，对心血管、中枢神经系统和代谢性疾病具有治疗潜力。

参考文献

[1]. Sun CP, et al. Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products. J Med Chem. 2021 Jan 14;64(1):184-215.