Somatic angiotensin-I-converting enzyme (sACE)

人体细胞血管紧张素i转换酶

英文解释

Human somatic angiotensin-I-converting enzyme (sACE) comprises two homologous metallopeptidase domains, N and C, joined by an inter-domain linker. Both domains are capable of cleaving the two hemoregulatory peptides angiotensin I and bradykini. sACE is a key regulator of blood pressure and an important drug target for combating cardiovascular and renal disease.

中文解释

人体细胞血管紧张素i转换酶 (sACE) 由两个同源金属肽酶结构域 N 和 C 组成，由结构域间连接子连接。这两个结构域都能分裂两种血液调节肽血管紧张素I和缓激肽。sACE 是一种关键的血压调节剂，也是治疗心血管和肾脏疾病的重要药物靶点。

参考文献

[1]. Hazel R Corradi, et al. Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design. J Mol Biol. 2006 Mar 31;357(3):964-74.