Stem cell factor (SCF)

干细胞因子

英文解释

Stem cell factor (SCF) is a dimeric molecule that exerts its biological functions by binding to and activating the receptor tyrosine kinase c-Kit. Signaling from c-Kit is crucial for normal hematopoiesis, pigmentation, fertility, gut movement, and some aspects of the nervous system.

中文解释

干细胞因子 (SCF) 是一种二聚体分子，通过结合并激活受体酪氨酸激酶 c-Kit 发挥其生物学功能。 来自 c-Kit 的信号对于正常的造血、色素沉着、生育能力、肠道运动和神经系统的某些方面至关重要。

参考文献

[1]. Johan Lennartsson, et al. Stem cell factor receptor/c-Kit: from basic science to clinical implications. Physiol Rev. 2012 Oct;92(4):1619-49.