Tropomyosin receptor kinase (TRK)

原肌凝蛋白受体激酶

英文解释

Tropomyosin receptor kinase (TRK) supports neuronal growth, survival, and differentiation during development, adult life, and aging. TRK downregulation is a prominent hallmark of various neurological disorders including Alzheimer's disease (AD). Abnormally expressed or overexpressed full-length or oncogenic fusion TRK proteins were shown to drive tumorigenesis in a variety of neurogenic and non-neurogenic human cancers.

中文解释

原肌凝蛋白受体激酶 (TRK) 在发育、成年和衰老过程中支持神经元的生长、存活和分化。TRK 下调是包括阿尔茨海默病 (AD) 在内的各种神经系统疾病的一个突出标志。在各种神经源性和非神经源性人类癌症中，异常表达或过表达的全长或癌源性融合 TRK 蛋白被证明可驱动肿瘤的发生。

参考文献

[1]. Schirrmacher R, et al. Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging. Pharmaceuticals (Basel). 2019 Jan 3;12(1):7.