β-site APP cleaving enzyme 1 (BACE1)
发布时间：2023-03-22 22:08:39
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β-site APP cleaving enzyme 1 (BACE1)
β 位点 APP 裂解酶
英文解释
β-Site APP-cleaving enzyme (BACE1) can cleave the amyloid precursor protein (APP) at the β-secretase site to initiate the production of Aβ peptides, which form toxic oligomers and the amyloid plaques associated with Alzheimer's disease (AD).
中文解释
β 位点 APP 裂解酶 (BACE1) 可以在 β 分泌酶位点裂解淀粉样蛋白前体蛋白 (APP) 以启动Aβ 肽的产生，这些 Aβ 肽可形成有毒的低聚物和与阿尔茨海默病 (Alzheimer's disease (AD)) 相关的淀粉样斑块。
参考文献
[1]. Tan J, et al. Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis. J Neurochem. 2012 Mar;120(6):869-80.
