A diterpene alkaloid with diverse biological activities
Delsoline is a diterpene alkaloid that has been found in Delphinium and has diverse biological activities.1,2,3 It inhibits binding of α-bungarotoxin to rat neuronal α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 19 ?M).1 Delsoline (3 mg/ml) is repellent against adult red flour beetles (T. castaneum) in a filter paper assay.2 In vivo, delsoline (75 mg/kg) lowers systolic blood pressure in a rat model of left renal artery ligation-induced hypertension.3
1.Hardick, D.J., Blagbrough, I.S., Cooper, G., et al.Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal alpha-bungarotoxin binding sites: Importance of the 2-(methylsuccinimido)benzoyl moiety for neuronal nicotinic acetylcholine receptor bindingJ. Med. Chem.39(24)4860-4866(1996) 2.Ulubelen, A., Meri?li, A.H., Kilin?er, N., et al.Insect repellent activity of diterpenoid alkaloidsPhytother. Res.15(2)170-171(2001) 3.Lian, Q.S., and Feng, G.H.Hypotensive effect of delsolineZhongguo Yaoli Xuebao6(1)37-40(1985)
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