A polyphenol with diverse biological activities
Dihydrocaffeic acid is a polyphenol that has diverse biological activities, including antioxidant, neuroprotective, and enzyme inhibitory properties.1,2 Dihydrocaffeic acid scavenges ABTS and 2,2-diphenyl-1-picrylhydrazyl radicals and increases the survival of RGC-5 mouse retinal ganglion cells under hypoxic conditions and in the presence of S-nitroso-N-acetyl-D,L-penicillamine in a concentration-dependent manner.1 It also decreases endothelial nitric oxide synthase (eNOS) activity in EA.hy926 human endothelial cells in a concentration-dependent manner.3 In vivo, dihydrocaffeic acid (30 mg/kg) decreases infarct size in a rat model of transient ischemia induced by middle cerebral artery occlusion (MCAO).2
1.Jang, H., Choi, Y., Ahn, H.R., et al.Effects of phenolic acid metabolites formed after chlorogenic acid consumption on retinal degeneration in vivoMol. Nutr. Food Res.59(10)1918-1929(2015) 2.Lee, K., Lee, B.J., and Bu, Y.Protective effects of dihydrocaffeic acid, a coffee component metabolite, on a focal cerebral ischemia rat modelMolecules20(7)11930-11940(2015) 3.Huang, J., De Paulis, T., and May, J.M.Antioxidant effects of dihydrocaffeic acid in human EA.hy926 endothelial cellsJ. Nutr. Biochem.15(12)722-729(2004)
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