An alkaloid with diverse biological activities
Tetrahydroepiberberine is an alkaloid originally isolated from P. rhoeas that has diverse biological activities.1,2 It is active against the fungus C. albicans (MIC = 8 ?g/ml), as well as the bacteria E. coli, P. aeruginosa, P. mirabilis, K. pneumoniae, A. baumannii, S. aureus, and B. subtilis (MICs = 32-64 ?g/ml, respectively).2 Tetrahydroepiberberine (16 ?g/ml) inhibits the cytopathogenic effect of parainfluenza-3 (PI-3) virus in Vero cells. It decreases the viability of HaCaT keratinocytes (IC50 = 150 ?M).1
1.Hijazi, M.A., Aboul-Ela, M., Bouhadir, K., et al.Cytotoxic activity of alkaloids from Papaver rhoeas growing in LebanonRec. Nat. Prod.11(2)211-216(2017) 2.Orhana, I., Oz?elik, B., Karao?lu, T., et al.Antiviral and antimicrobial profiles of selected isoquinoline alkaloids from Fumaria and Corydalis speciesZ. Naturforsch. C. J. Biosci.62(1-2)19-26(2007)
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