A synthetic curcuminoid and activator of TFEB
Curcumin analog C1 is a synthetic curcuminoid.1,2 It inhibits the proliferation of HCT116 colon cancer cells (GI50 = 4 ?M).1 Curcumin analog C1 (1 ?M) activates transcription factor EB (TFEB), inducing nuclear translocation in Neuro2a mouse neuroblastoma cells.2 It increases LC3-II levels and promotes autophagic flux in Neuro2a cells when used at a concentration of 1 ?M. Curcumin analog C1 (10 and 25 mg/kg, p.o.) activates TFEB and increases autophagy and lysosome biogenesis in rat brain.
1.Yamakoshi, H., Ohori, H., Kudo, C., et al.Structure-activity relationship of C5-curcuminoids and synthesis of their molecular probes thereofBioorg. Med. Chem.18(3)1083-1092(2010) 2.Song, J.-X., Sun, Y.-R., Peluso, I., et al.A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibitionAutophagy12(8)1372-1389(2016)
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