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Synthetic, pure inositol tetraphosphate for signal transduction research
D-myo-Inositol-2,3,4,5-tetraphosphate (Ins(2,3,4,5)-P4) is a member of the inositol phosphate (InsP) family of molecules that play a critical role as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)-P3, more commonly referred to as IP3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.
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