CU-32

A cGAS inhibitor

原价

￥1337-8012

价格

￥ 1070-6410

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库存: 现货

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产品引用

货号: ajcx22144
CAS: 2400954-16-5
别名:
分子式: C11H10IN5O2
分子量: 371.1
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
储存: Store at -20°C
库存: 现货

Background

CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC₅₀ = 0.45 µM).¹ It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 µM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 µM.

1.Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP synthase inhibitorsJ. Org. Chem.85(3)1579-1600(2020)

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CU-32

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Background