A neuropeptide with diverse biological activities
Decanoyl-coenzyme A (CoA) is a thioester of decanoic acid and CoA .1 It inhibits the activity of citrate synthase (CS) and glutamate dehydrogenase (GDH) in mitochondria isolated from rat brain (IC50s = 437 and 420 µM, respectively).2 Decanoyl-CoA also binds the fatty acid metabolism regulator protein (FadR) promoter in E. coli (Ki = 2 µM).3 It is produced during isomerase-dependent β-oxidation of oleic acid in isolated rat heart mitochondria.4
1.Gregersen, N., K?lvraa, S., and Mortensen, P.B.Acyl-CoA: Glycine N-acyltransferase: In vitro studies on the glycine conjugation of straight- and branched-chained acyl-CoA esters in human liverBiochem. Med. Metab. Biol.35(2)210-218(1986) 2.Lai, J.C., Lian, B.B., Zhai, S., et al.Brain mitochondrial citrate synthase and glutamate dehydrogenase: Differential inhibition by fatty acyl coenzyme A derivativesMetab. Brain Dis.9(2)143-152(1994) 3.DiRusso, C.C., Heimert, T.L., and Metzger, A.K.Characterization of FadR, a global transcriptional regulator of fatty acid metabolism in Escherichia coli. Interaction with the fadB promoter is prevented by long chain fatty acyl coenzyme AJ. Biol. Chem.267(12)8685-8691(1992) 4.Ren, Y., and Schulz, H.Metabolic functions of the two pathways of oleate β-oxidation double bond metabolism during the β-oxidation of oleic acid in rat heart mitochondriaJ. Biol. Chem.278(1)111-116(2003)
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