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  • Diclofenac-d4
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Diclofenac-d4

An internal standard for the quantification of diclofenac

原价
¥2275-4062
价格
1820-3250
Diclofenac-d4的二维码

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  • 货号: ajcx22268
  • CAS: 153466-65-0
  • 别名: 双氯芬酸 D4
  • 分子式: C14H7D4Cl2NO2
  • 分子量: 300.2
  • 纯度: >98%
  • 溶解度: DMSO: 35 mg/ml,Ethanol: 35 mg/ml,PBS (pH 7.2): 6 mg/ml,Water: 50 mg/ml
  • 储存: Store at Room temperature
  • 库存: 现货

Background

Diclofenac-d4 contains four deuterium atoms on the benzene ring. It is intended for use as an internal standard for the quantification of diclofenac by GC- or LC-mass spectrometry. Diclofenac is a non-selective COX inhibitor.1,2,3 It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively.1,2 Diclofenac inhibits ovine COX-1 and -2 with IC50 values of 60 and 220 nM, respectively.3



1.Laneuville, O., Breuer, D.K., DeWitt, D.L., et al.Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugsJ. Pharmacol. Exp. Ther.271(2)927-934(1994) 2.Barnett, J., Chow, J., Ives, D., et al.Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus systemBiochim Biophys. Acta.1209(1)130-139(1994) 3.Johnson, J.L., Wimsatt, J., Buckel, S.D., et al.Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledonsArch. Biochem. Biophys.324(1)26-34(1995)

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