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  • Diosmetin-d3
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Diosmetin-d3

An internal standard for the quantification of diosmetin

原价
¥1625-3112
价格
1300-2490
Diosmetin-d3的二维码

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  • 货号: ajcx22302
  • CAS: 1189728-54-8
  • 别名: 香叶木素 d3
  • 分子式: C16H9D3O6
  • 分子量: 303.3
  • 纯度: >98%
  • 溶解度: DMSO: slightly soluble,Methanol: slightly soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Diosmetin-d3 is intended for use as an internal standard for the quantification of diosmetin by GC- or LC-MS. Diosmetin is a flavonoid that has been found in citrus fruits and has diverse biological activities.1,2,3,4 It inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1 (Kis = 89 and 16 nM, respectively).1 Diosmetin prevents increases in erythrocyte reactive oxygen species (ROS) and malondialdehyde (MDA) levels induced by AAPH in a concentration-dependent manner.2 It reduces tumor growth and tumor blood vessel density in a B16/F10 murine melanoma model when administered at a dose of 1 mg/kg twice per day.3 Diosmetin (0.5 mg/kg) inhibits lung goblet cell hyperplasia and collagen deposition and decreases the number of eosinophils and neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of chronic asthma induced by ovalbumin.4



1.Androutsopoulos, V.P., Papakyriakou, A., Vourloumis, D., et al.Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoidsBioorg. Med. Chem.19(9)2842-2849(2011) 2.Liao, W., Ning, Z., Chen, L., et al.Intracellular antioxidant detoxifying effects of diosmetin on 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress through inhibition of reactive oxygen species generationJ. Agric. Food Chem.62(34)8648-8654(2014) 3.Choi, J., Lee, D.H., Park, S.Y., et al.Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancerBiomed. Pharmacother.117109091(2019) 4.Ge, A., Liu, Y., Zeng, X., et al.Effect of diosmetin on airway remodeling in a murine model of chronic asthmaActa Biochim. Biophys. Sin. (Shanghai)47(8)604-611(2015)

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