现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • Loratadine-d4
Loratadine-d4的可视化放大

Loratadine-d4

A neuropeptide with diverse biological activities

原价
¥1550-2950
价格
1240-2360
Loratadine-d4的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx22842
  • CAS: N/A
  • 别名: Loratidine-d4; SCH 29851-d4
  • 分子式: C22H19ClD4N2O2
  • 分子量: 386.9
  • 纯度: >98%
  • 溶解度: DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Loratadine-d4 is intended for use as an internal standard for the quantification of loratadine by GC- or LC-MS. Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM).1,2,3 It has been shown to inhibit the release of leukotriene C4 (IC50 = 8 µM) and histamine (IC50 = 11 µM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with an ED50 value of 0.40 mg/kg.4 Formulations containing loratadine have been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.



1.Ahn, H.S., and Barnett, A.Selective displacement of [3H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamineEur. J. Pharmacol.127(1-2)153-155(1986) 2.Kay, G.G., and Harris, A.G.Loratadine: A non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedationClin. Exp. Allergy29(Suppl 3)147-150(1999) 3.Barnett, A., Iorio, L.C., Kreutner, W., et al.Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamineAgents Actions43(3-4)149-156(1994) 4.Kreutner, W., Chapman, R.W., Gulbenkian, A., et al.Antiallergic activity of loratadine, a non-sedating antihistamineAllergy42(1)57-63(1987)

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服