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  • Meclizine-d8 (hydrochloride)
Meclizine-d8 (hydrochloride)的可视化放大

Meclizine-d8 (hydrochloride)

An internal standard for the quantification of meclizine

原价
¥2587-4875
价格
2070-3900
Meclizine-d8 (hydrochloride)的二维码

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  • 货号: ajcx22896
  • CAS: 1432062-16-2
  • 别名: Meclozine-d8 dihydrochloride
  • 分子式: C25H19ClD8N2.2HCl
  • 分子量: 471.9
  • 纯度: >98%
  • 溶解度: Chloroform: slightly soluble,Methanol: slightly soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Meclizine-d8 is intended for use as an internal standard for the quantification of meclizine by GC- or LC-MS. Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM).1 Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung.2 Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.



1.Tran, V.T., Chang, R.S.L., and Snyder, S.H.Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramineProc. Natl. Acad. Sci. U.S.A.75(12)6290-6294(1978) 2.Pasquale, C.P., e Silva, P.M., Lima, M.C., et al.Suppression by cetirizine of pleurisy triggered by antigen in actively sensitized ratsEur. J. Pharmacol.223(1)9-14(1992)

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