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  • Prostaglandin E1-d4
Prostaglandin E1-d4的可视化放大

Prostaglandin E1-d4

An internal standard for the quantification of prostaglandin E1

原价
￥950-7550
价格
￥ 760-6040
Prostaglandin E1-d4的二维码

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  • 库存: 现货
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  • 货号: ajcx23334
  • CAS: 211105-33-8
  • 别名: 前列地尔 d4
  • 分子式: C20H30D4O5
  • 分子量: 358.5
  • 纯度: >98%
  • 溶解度: DMF: >100 mg/ml (from PGE1),DMSO: >50 mg/ml (from PGE1),Ethanol: >50 mg/ml (from PGE1),PBS pH 7.2: >1.6 mg/ml (from PGE1)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Prostaglandin E1-d4 (PGE1-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGE1 by GC- or LC-mass spectrometry. PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals.1 Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.2,3 The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival.4,5 In human males, the intracavernosal effective dose range for PGE1 is 2 to 80 µg, and the transurethral range is 125 to 1,000 µg.4



1.Cawello, W., Schweer, H., Dietrich, B., et al.Pharmacokinetics of prostaglandin E1 and its main metabolites after intracavernous injection and short-term infusion of prostaglandin E1 in patients with erectile dysfunctionJournal of Urology1581403-1407(1997) 2.Kobzar, G., Mardla, V., J?rving, I., et al.Antiaggregating potency of E-type prostaglandins in human and rabbit plateletsProceedings of the Estonian Academy of Sciences.Chemistry40179-180(1991) 3.Okada, F., Nukada, T., Yamauchi, Y., et al.The hypotensive effect of prostaglandin E1 on hypertensive cases of various typesProstaglandins799-106(1974) 4.Padma-Nathan, H., Hellstrom, W.J.G., Kaiser, F.E., et al.Treatment of men with erectile dysfunction with transurethral alprostadilNew England Journal of Medicine3361-7(1997) 5.Olley, P.M., and Coceani, F.Prostaglandins and the ductus arteriosusAnnual Reviews of Medicine32375-3785(1981)

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