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  • PS-210
PS-210的可视化放大

PS-210

An activator of PDK1

原价
¥212-1600
价格
170-1280
PS-210的二维码

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  • 货号: ajcx23356
  • CAS: 1221962-86-2
  • 别名:
  • 分子式: C19H15F3O5
  • 分子量: 380.3
  • 纯度: >98%
  • 溶解度: DMSO: soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

PS-210 is an activator of phosphoinositide-dependent protein kinase 1 (PDK1) that increases its thermal stability.1,2 It is selective for PDK-1 over a panel of 120 kinases at 10 µM.1 PS-210 (2 µM) increases the activity of wild-type PDK1 but not PDK1 with a mutation in the PIF-binding pocket.



1.Busschots, K., Lopez-Garcia, L.A., Lammi, C., et al.Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking siteChem. Biol.19(9)1152-1163(2012) 2.Wilhem, A., Lopez-Garcia, L.A., Busschots, K., et al.2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: Development and prodrug conceptJ. Med. Chem.55(22)9817-9830(2012)

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