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  • Tamsulosin-d4 (hydrochloride)
Tamsulosin-d4 (hydrochloride)的可视化放大

Tamsulosin-d4 (hydrochloride)

A neuropeptide with diverse biological activities

原价
¥5312-5312
价格
4250-4250
Tamsulosin-d4 (hydrochloride)的二维码

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  • 库存: 现货
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  • 货号: ajcx23552
  • CAS: N/A
  • 别名: (R)-(-)-YM12617-d4; LY253351-d4
  • 分子式: C20H24D4N2O5S.HCl
  • 分子量: 449
  • 纯度: >98%
  • 溶解度: Methanol: slightly soluble,Water: slightly soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Tamsulosin-d4 is intended for use as an internal standard for the quantification of tamsulosin by GC- or LC-MS. Tamsulosin is a potent antagonist of α1-adrenergic receptors (α1-ARs; Ki = 0.229 nM in a radioligand binding assay).1 It is 3,800-fold selective for α1-ARs over α2-ARs (Ki = 871 nM). Tamsulosin antagonizes norepinephrine-induced contraction of isolated rabbit aorta (pA2 = 10.11) but has no effect on contraction stimulated by histamine, serotonin , angiotensin II , or prostaglandin F . In vivo, tamsulosin reverses the pressor effect of phenylephrine in pithed rats. It reversibly reduces fertility in male rats when administered at a dose of 0.15 mg/kg.2 Tamsulosin (1-100 μg/kg) also reduces prostatic pressure in a dose-dependent manner with minimal hypotensive effects in anesthetized dogs.3 Formulations containing tamsulosin have been used in the treatment of benign prostatic hyperplasia.



1.Honda, K., Takenaka, T., Miyata-Osawa, A., et al.Studies on YM-12617: A selective and potent antagonist of postsynaptic α1-adrenoceptorsNaunyn Schmiedebergs Arch. Pharmacol.328(3)264-272(1985) 2.Ratnasooriya, W.D., and Wadsworth, R.M.Tamsulosin, a selective alpha 1-adrenoceptor antagonist, inhibits fertility of male ratsAndrologia26(2)107-110(1994) 3.Sudoh, K., Tanaka, H., Inagaki, O., et al.Effect of tamsulosin, a novel alpha 1-adrenoceptor antagonist, on urethral pressure profile in anaesthetized dogsJ. Auton. Pharmacol.16(3)147-154(1996)

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