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  • PKA Inhibitor (5-24) (trifluoroacetate salt)
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PKA Inhibitor (5-24) (trifluoroacetate salt)

A synthetic peptide inhibitor of PKA

原价
¥1212-8475
价格
970-6780
PKA Inhibitor (5-24) (trifluoroacetate salt)的二维码

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  • 货号: ajcx23834
  • CAS: N/A
  • 别名: PKI (524), Protein Kinase A Inhibitor (524)
  • 分子式: C94H148N32O31?XCF3COOH
  • 分子量: 2222.4
  • 纯度: >98%
  • 溶解度: DMSO: 1 mg/ml,PBS (pH 7.2): 2 mg/ml
  • 储存: -20°C
  • 库存: 现货

Background

PKI PKA Inhibitor (5-24) is a synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM) derived from the active site of the skeletal muscle inhibitor protein.1 It mimics the protein substrate by binding to the catalytic site through the arginine-cluster basic subsite.1 The prominent enzyme-substrate interaction site occurs where PKA catalytic subunit residues Tyr235 and Phe239 form a sandwich-like structure with residue Phe10 of PKI (5-24).2



1.Cheng, H.C., Kemp, B.E., Pearson, R.B., et al.A potent synthetic peptide inhibitor of the cAMP-dependent protein kinaseThe Journal of Biological Chemisty261(3)989-992(1986) 2.Bossemeyer, D., Engh, R.A., Kinzel, V., et al.Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 ? structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24)EMBO Journal12(3)849-859(1993)

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