A lupane triterpenoid with anti-inflammatory and anticancer activities
28-Acetylbetulin is a lupane triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found in M. chiapensis and has anti-inflammatory and anticancer activities.1,2 It inhibits LPS-induced nitric oxide (NO) and prostaglandin E2 production by 55.9 and 69.5%, respectively, in RAW 264.7 cells (IC50s = 4.7 and 1.7 µM, respectively).1 28-Acetylbetulin induces cytotoxicity in a variety of cancer cells, including A549, HT-29, and MCF-7 cells (IC50s = 14.37, 10.96, and 11.38 µM, respectively).2
1.Reyes, C.P., Nú?ez, M.J., Jiménez, I.A., et al.Activity of lupane triterpenoids from Maytenus species as inhibitors of nitric oxide and prostaglandin E2Bioorg. Med. Chem.14(5)1573-1579(2006) 2.Kommera, H., Kaluderovi?, G.N., Kalbitz, J., et al.Lupane triterpenoids--betulin and betulinic acid derivatives induce apoptosis in tumor cellsInvest. New Drugs29(2)266-272(2011)
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