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A metabolite of griseofulvin
Griseofulvic acid is a metabolite of the antifungal griseofulvin .1 It induces protein aggregation and tubulin polymerization in cell-free assays.2
1.Zia, H., O'Donnell, J.P., and Ma, J.K.Identification of griseofulvic acid as a urine metabolite of griseofulvin in humansJ. Pharm. Sci.68(10)1335-1336(1979) 2.Mir, L., Oustrin, M.-L., Lecointe, P., et al.Correlation between the in vivo effects of some griseofulvin derivatives and their in vitro interactions with mammalian microtubulesFEBS Lett.88(2)259-263(1978)
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