An antiviral nucleoside analog
3′-deoxy Thymidine is a nucleoside analog of thymidine that has antiviral activity.1 It inhibits HIV replication in infected human peripheral blood mononuclear cells (PBMCs; EC50 = 0.17 µM).2 3′-deoxy Thymidine (1, 3, 10, or 30 µM) reduces viral plaque formation in CV-1 cells infected with herpes simplex virus 1 (HSV-1).1
1.Waqar, M.A., Evans, M.J., Manly, K.F., et al.Effects of 2’,3’-dideoxynucleosides on mammalian cells and virusesJ. Cell. Physiol.121(2)402-408(1984) 2.Lin, T.-S., Schinazi, R.F., and Prusoff, W.H.Potent and selective in vitro activity of 3’-deoxythymidin-2’-ene (3’-deoxy-2’,3’-didehydrothymidine) against human immunodeficiency virusBiochem. Pharmacol.36(17)2713-2718(1987)
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