Celecoxib Carboxylic Acid

An inactive metabolite of celecoxib

原价

￥1750-12100

价格

￥ 1400-9680

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库存: 现货

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产品引用

货号: ajcx25282
CAS: 170571-01-4
别名: 羧酸塞来昔布
分子式: C17H12F3N3O4S
分子量: 411.4
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:6): 0.12 mg/ml,PBS (pH 7.2): slightly soluble
储存: -20°C
库存: 现货

Background

Celecoxib carboxylic acid is an inactive metabolite of the COX-2 inhibitor celecoxib .^1,2 It is formed from celecoxib primarily by the cytochrome P450 (CYP) isoform CYP2C9.

1.Liu, H., Huang, X., Shen, J., et al.Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: Molecular docking and 3D QSAR analysesJ. Med. Chem.45(22)4816-4827(2002) 2.Kim, S.-H., Kim, D.-H., Byeon, J.-Y., et al.Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of celecoxib and its carboxylic acid metaboliteArch. Pharm. Res.40(3)382-390(2017)

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Celecoxib Carboxylic Acid

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Background