现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • Antisauvagine-30 (trifluoroacetate salt)
Antisauvagine-30 (trifluoroacetate salt)的可视化放大

Antisauvagine-30 (trifluoroacetate salt)

A peptide CRF2 antagonist

原价
¥5100-9200
价格
4080-7360
Antisauvagine-30 (trifluoroacetate salt)的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx25386
  • CAS: N/A
  • 别名: AS30, D-FHLLRKMIEIEKNEKEKNNAANNRLLLDTI-NH2, D-Phe11,His12Svg11-40, aSVG, aSvg-30
  • 分子式: C161H274N48O46S·XCF3COOH
  • 分子量: 3650.3
  • 纯度: >98%
  • 溶解度: Water: soluble
  • 储存: -20°C
  • 库存: 现货

Background

Antisauvagine-30 is a peptide antagonist of corticotropin-releasing factor receptor 2 (CRF2).1,2 It is selective for CRF over CRF1 (Kis = 1.75 and 915 nM, respectively for the human receptors).1 Antisauvagine-30 (10 nM) inhibits sauvagine-induced cAMP production in HEK293 cells expressing mouse CRF.2 It prevents stress-induced contextual fear conditioning in mice.3 Antisauvagine-30 reduces vasoactive intestinal peptide-induced decreases in food intake in rats.4



1.Dautzenberg, F.M., Py-Lang, G., Higelin, J., et al.Different binding modes of amphibian and human corticotropin-releasing factor type 1 and type 2 receptors: Evidence for evolutionary differencesJ. Pharmacol. Exp. Ther.296(1)113-120(2001) 2.Rühmann, A., Bonk, I., Lin, C.R., et al.Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): Development of CRFR2β-selective antisauvagine-30Proc. Natl. Acad. Sci. USA95(26)15264-15269(1998) 3.Sananbenesi, F., Fischer, A., Schrick, C., et al.Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: A possible link between stress and fear memoryJ. Neurosci.23(36)11436-11443(2003) 4.Garnica-Siqueira, M.C., Martins, A.B., Zaia, D.A.M., et al.Corticotrophin-releasing factor mediates vasoactive intestinal peptide-induced hypophagia and changes in plasma parametersHorm. Behav.105138-145(2018)

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服