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An internal standard for the quantification of N-desmethyl ivabradine
rac-N-desmethyl Ivabradine-d6 is intended for use as an internal standard for the quantification of N-desmethyl ivabradine by GC- or LC-MS. N-desmethyl Ivabradine is an active metabolite of ivabradine .1 Ivabradine is metabolized by the cytochrome P450 (CYP) isoform CYP3A4.
1.Rosa, G.M., Ferrero, S., Ghione, P., et al.An evaluation of the pharmacokinetics and pharmacodynamics of ivabradine for the treatment of heart failureExpert Opin. Drug Metab. Toxicol.10(2)279-291(2014)
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