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  2. Ribosomal S6 Kinase (RSK)
  3. Difelikefalin (trifluoroacetate salt)
  • Difelikefalin (trifluoroacetate salt)
Difelikefalin (trifluoroacetate salt)的可视化放大

Difelikefalin (trifluoroacetate salt)

A κ-opioid receptor agonist

原价
￥1837-13575
价格
￥ 1470-10860
Difelikefalin (trifluoroacetate salt)的二维码

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  • 库存: 现货
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  • 货号: ajcx25570
  • CAS: N/A
  • 别名: CR845, FE 202845
  • 分子式: C36H53N7O6·XCF3COOH
  • 分子量: 679.9
  • 纯度: >98%
  • 溶解度: Ethanol: soluble
  • 储存: -20°C
  • 库存: 现货

Background

Difelikefalin is a κ-opioid receptor (KOR) agonist.1 It activates KOR in HEK293 cells expressing the human receptor (EC50 = 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 mouse thyoma cells (EC50 = 0.048 nM). Difelikefalin is selective for KOR over the μ-opioid receptor (MOR; EC50 = >1 µM in a transactivation assay). It reduces acetic acid-induced writhing, as well as scratching behavior induced by the KOR antagonist GNTI, in mice (ED50s = 0.07 and 0.05 mg/kg, respectively).



1.Schteingart, C.D., Menzaghi, F., Jiang, G., et al.Synthetic peptide amides(2008)

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