An alkaline phosphatase inhibitor
4-Aminobenzylphosphonic acid is an inhibitor of alkaline phosphatase (Ki = 1.1 mM for the bovine intestine enzyme).1 It has been used in affinity chromatography for the purification of alkaline phosphatase. 4-Aminobenzylphosphonic acid has also been used in electrochemical modification of glassy carbon electrodes.2
1.Landt, M., Boltz, S.C., and Butler, L.G.Alkaline phosphatase: Affinity chromatography and inhibition by phosphonic acidsBiochemistry17(5)915-919(1978) 2.Benjamin, O.D., Weissmann, M., and Bélanger, D.Electrochemical modification of carbon electrode with benzylphosphonic groupsElectrochim. Acta122210-217(2014)
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