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  • JTV 519 fumarate
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JTV 519 fumarate

Ryanodine receptor (RyR) inhibitor

原价
¥3412-14062
价格
2730-11250
JTV 519 fumarate的二维码

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  • 库存: 现货
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  • 货号: ajcx26852
  • CAS: 1883549-36-7
  • 别名:
  • 分子式: C25H32N2O2.C4H4O4
  • 分子量: 540.67
  • 纯度: >98%
  • 溶解度: 54.07mg/ml in DMSO
  • 储存: Store at 4°C
  • 库存: 现货

Background

Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.



Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431 PMID:17313373 |Chen et al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915 PMID:17994112 |Ye et al (2012) Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol.Pharmacol. 81 53 PMID:21989257

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