安捷凯在线客服
- 客服:
- 电话: 13061953619
- 微信:
INF 4E 是一种有效的 NLRP3 炎性体抑制剂。
NLRP3 inflammasome and caspase-1 inhibitor (Ki = 9.6 μM for caspase-1). Inhibits Nigericin or ATP (Cat.No. 3245) induced pyroptosis of PMA-differentiated and LPS-primed THP-1 cells and activates the Keap1-Nrf2 pathway.
Cocco et al (2014) Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J.Med.Chem. 57 10366 PMID:25418070
动态评分
0.0